Question 1

If the CH50 is lower than normal but the AH50 is normal, which set contains the components that could be involved?

Accepted Answer

A)  factor B, factor D, and Properdin
B)  MBL, MASP-1, MASP-2
C)  C1, C4, C2, C1INH
D)  C5-9E) A) and B)
F) A) and C) C

Question 2

C1q can

Accepted Answer

A)  bind free-floating IgM that is not bound to antigen
B)  become activated after interaction with one surface-bound antibody
C)  bind after a conformational change occurs as the result of antigen binding
D)  bind IgG4E) A) and D)
F) All of the above

Question 3

Complement has

Accepted Answer

A)  about 9 different proteins that are synthesized by monocytes
B)  about 35 different proteins that are synthesized by monocytes
C)  about 9 different proteins that are synthesized by monocytes, the liver, macrophages, and epithelial cells
D)  about 35 different proteins that are synthesized by monocytes, the liver, macrophages, and epithelial cellsE) A) and B)
F) B) and C)

Question 4

Which of the following is correct?

Accepted Answer

A)  C1INH inactivates C1 and inhibits binding of MBL to MASP-2.
B)  factor D inhibits factor B and Properdin.
C)  DAF inhibits C1q binding to C1r and C1s.
D)  CR2 inhibits C3b formation.E) A) and B)
F) A) and C)

Question 5

Because a particular antigen is far on the bacteria from another antigen, antibodies binding to these antigens

Accepted Answer

A)  would activate complement only if antibodies bound to them underwent a comformational shift
B)  would activate complement only if antibodies bound to them were close enough for the Fc regions of the bound antibodies to bind different globular heads of the C1q molecule
C)  would activate complement only if antibodies bound to them underwent a comformational shift and would activate complement only if antibodies bound to them were close enough for the Fc regions of the bound antibodies to bind different globular heads of the C1q molecule
D)  none of the aboveE) None of the above
F) B) and D)

Question 6

C-reactive protein can

Accepted Answer

A)  activate complement in the classical pathway
B)  activate complement in the lectin pathway
C)  activate complement in the alternative pathway
D)  activate complement in the classical pathway and activate complement in the alternative pathwayE) A) and B)
F) A) and C)

Question 7

Properdin is a

Accepted Answer

A)  complemencomponent of the classical pathway
B)  complement protein of the alternative pathway
C)  complement protein of the lectin pathway
D)  defensinE) A) and B)
F) None of the above

Question 8

Which is involved in immune complex clearance by phagocytosis or splenic clearance?

Accepted Answer

A)  CR1
B)  CR2
C)  CR3
D)  CR1 and CR3E) B) and C)
F) A) and D) A

Question 9

Complement proteins are involved in all of the following except

Accepted Answer

A)  host defense
B)  immune complex clearance
C)  interaction with the coagulation pathway
D)  lattice formation
E)  enhancement of memoryF) A) and E)
G) A) and D) D

Question 10

Calcium ions are required

Accepted Answer

A)  to keep C4bC2a together
B)  to keep C6,7,8 together
C)  to allow C9 to polymerize
D)  to keep C1q,r,s togetherE) B) and C)
F) A) and D)

Question 11

Individual complement components measured with

Accepted Answer

A)  AH50
B)  CH50
C)  RID
D)  bacterial cell lysisE) B) and C)
F) B) and D)

Question 12

Which of the following are anaphylatoxins?

Accepted Answer

A)  C1q, C2a, C4a
B)  C2b, C4a, C5a
C)  C2a, C4a, C5a
D)  C3a, C4a, C5aE) All of the above
F) None of the above

Question 13

Which of the following are all opsonic molecules?

Accepted Answer

A)  C3b, C1q, iC3b, C4b
B)  C2a, C1q, C3b
C)  C2b, C3b, C4b
D)  C3b, C4b, C9E) None of the above
F) B) and C)

Question 14

To study antibody in a patient's blood in a way that removes the complement,

Accepted Answer

A)  freeze and thaw the serum
B)  use serum instead of plasma
C)  add LPS and then heat to 100°C for 2 minutes
D)  heat the serum to 56oC for 30 minutesE) B) and D)
F) B) and C)

Question 15

The three different pathways of complement activation are

Accepted Answer

A)  different until the C5 convertase is formed
B)  different until the membrane attack complex forms
C)  different until activation of C3
D)  different until C6 convertase formsE) A) and B)
F) A) and C)

Question 16

We would expect that a patient who has chronic liver disease would have complement levels that would be

Accepted Answer

A)  elevated
B)  normal
C)  decreased
D)  indeterminate because there is too little informationE) B) and C)
F) C) and D)

Question 17

The factors in the alternative pathway that are involved in the progression of the pathway are_______ and ___________. The factors that are involved in inhibition of the pathway are _____ and _________.

Accepted Answer

A)  Factor C and D , Factor Properdin and Factor I
B)  Factor B and D , Factor E and F
C)  Factor B and D, Factor ficolin and Factor I
D)  Factor B and D, Factor H and IE) C) and D)
F) A) and D)

Question 18

Which of the following has a short half-life unless it lands on the cell surface?

Accepted Answer

A)  C4b
B)  C2b
C)  C5a
D)  C3aE) A) and B)
F) All of the above

Question 19

Inhibitors of complement include

Accepted Answer

A)  factors I, H, and C1INH
B)  vitronectin or S protein
C)  CR3
D)  factors I, H, and C1INH and vitronectin or S protein
E)  All of the aboveF) B) and C)
G) A) and E)

Question 20

Complement can lyse which of the following cells?

Accepted Answer

A)  fungal cells
B)  gram-positive bacteria
C)  gram-negative bacteria
D)  all of the aboveE) A) and B)
F) None of the above

Exam 5: Complement Pathways

If the CH50 is lower than normal but the AH50 is normal, which set contains the components that could be involved?

Correct AnswerverifiedC

C1q can

Correct AnswerverifiedShow Answer

Complement has

Correct AnswerverifiedShow Answer

Which of the following is correct?

Correct AnswerverifiedShow Answer

Because a particular antigen is far on the bacteria from another antigen, antibodies binding to these antigens

Correct AnswerverifiedShow Answer

C-reactive protein can

Correct AnswerverifiedShow Answer

Properdin is a

Correct AnswerverifiedShow Answer

Which is involved in immune complex clearance by phagocytosis or splenic clearance?

Correct AnswerverifiedA

Complement proteins are involved in all of the following except

Correct AnswerverifiedD

Calcium ions are required

Correct AnswerverifiedShow Answer

Individual complement components measured with

Correct AnswerverifiedShow Answer

Which of the following are anaphylatoxins?

Correct AnswerverifiedShow Answer

Which of the following are all opsonic molecules?

Correct AnswerverifiedShow Answer

To study antibody in a patient's blood in a way that removes the complement,

Correct AnswerverifiedShow Answer

The three different pathways of complement activation are

Correct AnswerverifiedShow Answer

We would expect that a patient who has chronic liver disease would have complement levels that would be

Correct AnswerverifiedShow Answer

The factors in the alternative pathway that are involved in the progression of the pathway are_______ and ___________. The factors that are involved in inhibition of the pathway are _____ and _________.

Correct AnswerverifiedShow Answer

Which of the following has a short half-life unless it lands on the cell surface?

Correct AnswerverifiedShow Answer

Inhibitors of complement include

Correct AnswerverifiedShow Answer

Complement can lyse which of the following cells?

Correct AnswerverifiedShow Answer

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C

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A

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D

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The factors in the alternative pathway that are involved in the progression of the pathway are_ and ___. The factors that are involved in inhibition of the pathway are _ and _______.

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