Question 1

Complement

Accepted Answer

A)  causes lysis of gram-positive cells and has no effect on gram-negative cells
B)  causes lysis of gram-negative cells and has no effect on gram-positive cells
C)  causes lysis of gram-positive cells and increases the amount of phagocytosis of gram-negative cells
D)  causes lysis of gram-negative cells and increases the amount of phagocytosis of gram-positive cellsE) A) and B)
F) A) and C)

Question 2

The AH50 differs from the CH50 because the AH50

Accepted Answer

A)  measures the alternative pathway and the CH50 measures the classical pathway
B)  measures the classical pathway and the CH50 measures the alternative pathway
C)  uses rabbit red blood cells and the CH50 uses sheep red blood cells with antibody
D)  measures the alternative pathway and the CH50 measures the classical pathway and uses rabbit red blood cells and the CH50 uses sheep red blood cells with antibody
E)  measures the classical pathway and the CH50 measures the alternative pathway and uses rabbit red blood cells and the CH50 uses sheep red blood cells with antibodyF) D) and E)
G) A) and B)

Question 3

The difference in the three pathways is the way the C3 convertase is formed

Accepted Answer

A)  in the classical pathway, the C3 convertase is C1C2; in the alternative pathway, it is C3wBb; and in the MBL pathway, the C3 convertase is C2aC4b
B)  in the classical pathway, the C3 convertase is C2aC4b' in the alternative pathway, it is C3wBb; and in the MBL pathway, the C3 convertase is C2aC4b
C)  in the classical pathway, the C3 convertase is C1C2; in the alternative pathway, it is C3wBb; and in the MBL pathway, the C3 convertase is MBL-MASP-2
D)  in the classical pathway, the C3 convertase is C2aC4b; in the alternative pathway, it is PDBb; and in the MBL pathway, the C3 convertase is C2aC4bE) B) and C)
F) A) and B)

Question 4

Sometimes a microorganism can directly activate complement through

Accepted Answer

A)  the alternative pathway only
B)  the lectin pathway only
C)  the alternative and the lectin pathway
D)  usually the alternative and the lectin pathways, but with some microorganisms, also the classical pathwayE) C) and D)
F) B) and D)

Question 5

Which pathway(s)  can act as a powerful amplifier of the other pathways?

Accepted Answer

A)  the classical pathway
B)  the alternative pathway
C)  the lectin pathway
D)  all of the pathways can amplify each otherE) B) and C)
F) A) and B)

Question 6

Collectin is

Accepted Answer

A)  another name for the mannose-binding lectin
B)  a name for the collective processes involved in all complement pathways
C)  a receptor for C3b
D)  a receptor for C1qE) A) and C)
F) None of the above

Question 7

Which of the following is an active C3 convertase?

Accepted Answer

A)  C4bC2a
B)  C3bC5b
C)  C4bC2a.
D)  BbDdE) B) and D)
F) None of the above

Question 8

Complement proteins are synthesized by

Accepted Answer

A)  the liver
B)  monocytes
C)  macrophages
D)  epithelial cells
E)  All of the aboveF) All of the above
G) C) and E)

Question 9

MBL binds

Accepted Answer

A)  mannose and MASP-2 become associated and cleave C2 and C4
B)  mannose and MASP-1 become associated and cleave C4
C)  ficolin and MASP-2 become associated and cleave C2 and C4
D)  membranes and MASP-1 become associated and cleave C2 and C4E) A) and B)
F) None of the above

Question 10

Susie has an acute infection-strep throat-and her friend Zoe has a chronic illness, systemic lupus erythematosus.

Accepted Answer

A)  Susie probably has an elevated CH 50 while Zoe probably has a decreased CH50.
B)  Susie probably has a decreased CH 50 while Zoe probably has an increased CH50.
C)  Both Susie and Zoe probably have an elevated CH 50.
D)  Both Susie and Zoe probably have a decreased CH 50.E) A) and B)
F) A) and C)

Question 11

Anaphylatoxins include

Accepted Answer

A)  C5a
B)  C4a
C)  C3a
D)  C5a and C4a
E)  all of the aboveF) A) and D)
G) All of the above

Question 12

Complement

Accepted Answer

A)  aids in immune complex clearance
B)  interacts with the coagulation pathway
C)  can be involved in immune memory enhancement
D)  all of the above
E)  A and C onlyF) A) and E)
G) All of the above

Question 13

What molecule is needed for C1q,r and s to stay together?

Accepted Answer

A)  Mg++
B)  Ca++ and Mg++
C)  Ca++
D)  none of the aboveE) C) and D)
F) None of the above

Question 14

Amplification steps in the complement pathways occur

Accepted Answer

A)  in the classical pathway with C1 cleaving multiple molecules of C4 and multiple C2 for every C1 and C4; in the alternative pathway with the C3b of other pathways becoming C3 convertase; and then the C3b becoming part of a C5 convertase
B)  in all pathways with all the C3 convertases making multiple C3a +C3b
C)  with C9 polymerization
D)  all of the above
E)  A and B onlyF) B) and C)
G) B) and E)

Exam 5: Complement Pathways

Sometimes a microorganism can directly activate complement through

Correct Answer
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Complement

Correct Answer
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Amplification steps in the complement pathways occur

Correct Answer
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Complement proteins are synthesized by

Correct Answer
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Which of the following is an active C3 convertase?

Correct Answer
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What molecule is needed for C1q,r and s to stay together?

Correct Answer
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The difference in the three pathways is the way the C3 convertase is formed

Correct Answer
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Complement

Correct Answer
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Anaphylatoxins include

Correct Answer
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Susie has an acute infection-strep throat-and her friend Zoe has a chronic illness, systemic lupus erythematosus.

Correct Answer
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Which pathway(s) can act as a powerful amplifier of the other pathways?

Correct Answer
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Collectin is

Correct Answer
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The AH50 differs from the CH50 because the AH50

Correct Answer
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MBL binds

Correct Answer
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Exam 5: Complement Pathways

Sometimes a microorganism can directly activate complement through

Correct AnswerverifiedShow Answer

Complement

Correct AnswerverifiedShow Answer

Amplification steps in the complement pathways occur

Correct AnswerverifiedShow Answer

Complement proteins are synthesized by

Correct AnswerverifiedShow Answer

Which of the following is an active C3 convertase?

Correct AnswerverifiedShow Answer

What molecule is needed for C1q,r and s to stay together?

Correct AnswerverifiedShow Answer

The difference in the three pathways is the way the C3 convertase is formed

Correct AnswerverifiedShow Answer

Complement

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Anaphylatoxins include

Correct AnswerverifiedShow Answer

Susie has an acute infection-strep throat-and her friend Zoe has a chronic illness, systemic lupus erythematosus.

Correct AnswerverifiedShow Answer

Which pathway(s) can act as a powerful amplifier of the other pathways?

Correct AnswerverifiedShow Answer

Collectin is

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The AH50 differs from the CH50 because the AH50

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MBL binds

Correct AnswerverifiedShow Answer

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