Question 1

Which are common protein coenzymes?

Accepted Answer

A)   cytochromes
B)   phylloquinones
C)   tetrahydrofolates
D)   α-tocopherolsE) None of the above
F) B) and D)

Question 2

Which vitamin is shown below? 1)  C)  cobalamin vitamin B12)  D)  folate" class="answers-bank-image d-inline" rel="preload" >

Accepted Answer

A)   vitamin C
B)   thiamin vitamin B1) 
C)   cobalamin vitamin B12) 
D)   folateE) A) and B)
F) A) and C)

Question 3

Which amino acid can form a covalent bond to the coenzyme pyridoxal phosphate?

Accepted Answer

A)   aspartate
B)   cysteine
C)   lysine
D)   serineE) A) and D)
F) B) and D)

Question 4

The structure shown below is which coenzyme? 2  B)  Vitamin B12 C)  Biotin D)  Thiamine pyrophosphate" class="answers-bank-image d-inline" rel="preload" >

Accepted Answer

A)   QH2 
B)   Vitamin B12
C)   Biotin
D)   Thiamine pyrophosphateE) A) and B)
F) B) and C)

Question 5

Protein catalysts rely exclusively on the amino acid residues for reactivity at the sites of action.

Accepted Answer

A) True 
 B)False

Question 6

Structures of several dehydrogenases indicate that many possess one or more similar NAD or NADP-binding structures consisting of babab units in Rossman folds.

Accepted Answer

A) True 
 B)False

Question 7

Minerals which are cofactors may be reversibly bound and are then usually directly involved in catalytic reactions.

Accepted Answer

A) True 
 B)False

Question 8

An internal aldimine forms when PLP is covalently bound to its enzyme.

Accepted Answer

A) True 
 B)False

Question 9

What is the role of the magnesium ion in kinases that require the magnesium-ATP complex to donate phosphoryl groups?

Accepted Answer

A)   maintain the configuration of the holoenzyme
B)   shield the charged phosphate groups of ATP
C)   produce an electrophilic attack on the substrate
D)   promote ionization of bound water
E)   produce ionization of the substrate to be phosphorylatedF) A) and E)
G) D) and E)

Question 10

Which type of atom is involved in the reactive center of lipoamide?

Accepted Answer

A)   sulfur
B)   nitrogen
C)   phosphorous
D)   oxygenE) B) and D)
F) All of the above

Question 11

Match each of the following vitamins with an associate nutritional deficiency disease. 
-Ascorbate

Accepted Answer

The answer of Match each of the following vitamins with...

Question 12

Cobalamin is synthesized by most organisms from simple precursors and does not need to be in the diet.

Accepted Answer

A) True 
 B)False

Question 13

Ca++ or Mg++ are most likely to be part of , while Zn++ or Fe++ are present in .

Accepted Answer

A)   metal-activated enzymes; metalloenzymes
B)   metalloenzymes; metal-activated enzymes
C)   cofactors; coenzymes
D)   coenzymes; cofactors
E)   apoenzymes; holoenzymesF) None of the above
G) A) and B)

Question 14

Another name for α-tocopherol is vitamin .

Accepted Answer

A)   A
B)   B12 
C)   C
D)   D
E)   EF) None of the above
G) A) and B)

Question 15

Match each of the following vitamins with an associate nutritional deficiency disease. 
-Folate

Accepted Answer

The answer of Match each of the following vitamins with...

Question 16

Which statement is false about 5,6,7,8-tetrahydrobiopterin?

Accepted Answer

A)   It is required by the enzyme that catalyzes the synthesis of nitric oxide from arginine.
B)   It is synthesized by animals and other organisms.
C)   It is used in the transfer of phosphate groups during DNA synthesis.
D)   It is a reducing agent in the conversion of phenylalanine to tyrosine.E) A) and D)
F) A) and B)

Question 17

NAD and NADP dependent dehydrogenases catalyze substrates by transferring to C-4 of NAD+ and NADP+.

Accepted Answer

A)   one electron
B)   two electrons
C)   one electron and one proton
D)   two electrons and one proton
E)   two electrons and two protonsF) A) and B)
G) A) and E)

Question 18

What kind of reaction is most important for the reactive center of lipoamide?

Accepted Answer

A)   oxidation of a carbonyl group
B)   reduction of a disulfide bond
C)   formation of a Schiff base
D)   a cis-trans configurational change about a disulfide bondE) C) and D)
F) All of the above

Question 19

Match each of the following vitamins with an associate nutritional deficiency disease. 
-Thiamine B1)

Accepted Answer

Question 20

The role of zinc in the mechanisms of carbonic anhydrase is to

Accepted Answer

A)   maintain the configuration of the holoenzyme.
B)   bind to three histidine residues.
C)   produce a nucleophilic attack on the substrate.
D)   promote ionization of bound water.
E)   produce an electrophilic attack on the substrate.F) A) and D)
G) None of the above

Exam 7: Coenzymes and Vitamins

What is the role of the magnesium ion in kinases that require the magnesium-ATP complex to donate phosphoryl groups?

Correct AnswerverifiedShow Answer

Structures of several dehydrogenases indicate that many possess one or more similar NAD or NADP-binding structures consisting of babab units in Rossman folds.

Correct AnswerverifiedShow Answer

Match each of the following vitamins with an associate nutritional deficiency disease. -Ascorbate

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What kind of reaction is most important for the reactive center of lipoamide?

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Match each of the following vitamins with an associate nutritional deficiency disease. -Folate

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The role of zinc in the mechanisms of carbonic anhydrase is to

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Which amino acid can form a covalent bond to the coenzyme pyridoxal phosphate?

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Which type of atom is involved in the reactive center of lipoamide?

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Match each of the following vitamins with an associate nutritional deficiency disease. -Thiamine B1)

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NAD and NADP dependent dehydrogenases catalyze substrates by transferring to C-4 of NAD+ and NADP+.

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Ca++ or Mg++ are most likely to be part of , while Zn++ or Fe++ are present in .

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Which statement is false about 5,6,7,8-tetrahydrobiopterin?

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Protein catalysts rely exclusively on the amino acid residues for reactivity at the sites of action.

Correct AnswerverifiedShow Answer

An internal aldimine forms when PLP is covalently bound to its enzyme.

Correct AnswerverifiedShow Answer

Another name for α-tocopherol is vitamin .

Correct AnswerverifiedShow Answer

Cobalamin is synthesized by most organisms from simple precursors and does not need to be in the diet.

Correct AnswerverifiedShow Answer

Which are common protein coenzymes?

Correct AnswerverifiedShow Answer

Minerals which are cofactors may be reversibly bound and are then usually directly involved in catalytic reactions.

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The structure shown below is which coenzyme?

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Which vitamin is shown below?

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Match each of the following vitamins with an associate nutritional deficiency disease. -Thiamine B₁)

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NAD and NADP dependent dehydrogenases catalyze substrates by transferring to C-4 of NAD⁺and NADP⁺.

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Ca⁺⁺or Mg⁺⁺are most likely to be part of , while Zn⁺⁺or Fe⁺⁺are present in .

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