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A channel that opens in response to the binding of a specific molecule, which is usually not the solute that passes through the channel is called a ________.


A) voltage-gated channel
B) charge-gated channel
C) ligand-gated channel
D) positive-gated channel
E) electric-gated channel

F) A) and B)
G) A) and E)

Correct Answer

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What kind of membrane protein is found entirely outside the bilayer on either the extracellular or cytoplasmic surface and is covalently linked to a membrane lipid situated within the bilayer?


A) integral protein
B) lipid-anchored protein
C) peripheral proteins
D) carbohydrate-anchored protein
E) transmembrane

F) All of the above
G) A) and D)

Correct Answer

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What causes the membrane potential to return to the normal negative value after an action potential has occurred?


A) opening of a voltage-gated K+ channel
B) opening of a voltage-gated Na+ channel
C) closing of a voltage-gated K+ channel
D) opening of a ligand-gated Na+ channel
E) opening of a voltage-gated K+ facilitated transporter

F) D) and E)
G) A) and B)

Correct Answer

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A channel that opens in response to changes in ionic charge across a membrane is called a ________.


A) voltage-gated channel
B) charge-gated channel
C) ligand-gated channel
D) positive-gated channel
E) electric-gated channel

F) A) and B)
G) A) and C)

Correct Answer

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A

How is a nerve impulse usually transmitted across a synapse from a presynaptic to a postsynaptic cell?


A) via a direct connection
B) via a spark
C) via a neurotransmitter
D) via Na+ ions
E) via plasmodesmata

F) A) and E)
G) A) and B)

Correct Answer

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Diffusion during which the substance to be transported binds selectively to a membrane-spanning protein, which helps the process along, is called ________.


A) osmosis
B) facilitated osmosis
C) simple diffusion
D) facilitated diffusion
E) active transport

F) A) and B)
G) A) and E)

Correct Answer

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A procedure in which the gene for an integral membrane protein is altered in such a way that the spatial relationships between some of the amino acids in the protein can be revealed is called ________.


A) site-directed mutagenesis
B) site-directed hydropathy
C) hydropathy plots
D) electron paramagnetic resonance (EPR) spectroscopy
E) infrared spectroscopy

F) A) and B)
G) A) and E)

Correct Answer

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Why would a transverse diffusion or flip-flop of membrane phospholipids from one leaflet to the other be so rare?


A) Flippases are enzymes which are transiently stable and expressed at low concentrations.
B) For flip-flop to occur, it would be necessary for the hydrophilic head of a phospholipid to move through the hydrophobic part of the bilayer, an extremely unlikely event.
C) For flip-flop to occur, it would be necessary for the hydrophobic head of a phospholipid to move through the hydrophilic part of the bilayer, an extremely unlikely event.
D) Other membrane activities like flexing and lateral shift inhibit phospholipid flip-flop.

E) All of the above
F) A) and B)

Correct Answer

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Long-term potentiation is associated with NMDA receptors, one of several types of receptors that bind to the excitatory neurotransmitter __________. Its binding opens an internal cation channel within the receptor that allows __________ influx into the postsynaptic neuron, triggering a cascade of biochemical changes that lead to synaptic strengthening.


A) GABA, Ca2+ ion
B) glutamate, Ca2+ ion
C) glutamate, K+ ion
D) GABA, K+ ion
E) acetylcholine, Ca2+ ion

F) A) and C)
G) All of the above

Correct Answer

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Which protein(s) below is(are) thought to be involved in and influence the stability of red blood cell membranes and the cells themselves by imparting strength, elasticity, and pliability to the membrane?


A) actin and tropomyosin
B) spectrin
C) band 3
D) ankyrin
E) all of these are correct

F) B) and D)
G) B) and C)

Correct Answer

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Which part of a neuron conducts impulses away from the cell body toward the target cell(s) ?


A) axon hillock
B) cell body
C) dendrites
D) axon
E) terminal knob

F) B) and D)
G) B) and C)

Correct Answer

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Gorter and Grendel extracted lipids from human red blood cells. They calculated the total surface area for these red blood cell lipids and found it to be 36 µm2. How much surface area would these lipids cover once they were spread across the surface of water?


A) 72 µm2
B) 36 µm2
C) 18 µm2
D) 144 µm2
E) 30 µm2

F) A) and D)
G) A) and C)

Correct Answer

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When membrane lipids are extracted from cells and used to prepare artificial lipid bilayers, cholesterol and sphingolipids tend to self-assemble into ________ that are more gelated and highly ordered than surrounding regions consisting primarily of _________.


A) macrodomains, phosphoglycerides
B) microdomains, integral proteins
C) microdomains, phosphoglycerides
D) liquid crystals, phosphoglycerides
E) liquid crystals, microdomains

F) B) and C)
G) A) and E)

Correct Answer

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Which site in a neuron receives incoming information from external sources?


A) Dendrites
B) Axon
C) Axon hillock
D) Terminal knob
E) Cell body

F) A) and B)
G) A) and C)

Correct Answer

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A

How do Na+ ions enter a neuron when an action potential is initiated?


A) the Na+/K+-ATPase
B) a gated Na+ pump
C) a voltage-gated Na+ channel
D) the ligand-gated Na+ channel
E) a voltage-gated Na+ facilitated transporter

F) A) and E)
G) None of the above

Correct Answer

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C

In the Na+/glucose cotransporter, _________ moving down its gradient drives the transport of __________ against its gradient.


A) Na+ ions, K+ ions
B) Na+ ions, glucose
C) glucose, Na+ ions
D) glucose, K+ ions
E) K+ ions, glucose

F) A) and B)
G) All of the above

Correct Answer

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Which of the following is NOT a potential biological role of the lipid asymmetry of the plasma membrane?


A) The glycolipids in the outer leaflet of the membrane may serve as receptors.
B) The presence of phosphatidylinositol primarily in the inner leaflet is involved in signal transduction.
C) The cell has the ability to maintain a charge differential in the two membrane leaflets.
D) Appearance of phosphatidylserine on the outer surface of aging lymphocytes marks them for destruction by macrophages.
E) Phosphatidylserine on the surface of platelets serves as a signal for blood solubilization.

F) B) and D)
G) None of the above

Correct Answer

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Which of the following cell processes depend on the movement of membrane components and would probably not be possible if membranes were rigid, nonfluid structures?


A) cell movement
B) cell division
C) formation of intercellular junctions
D) endocytosis
E) all of these are correct

F) C) and D)
G) D) and E)

Correct Answer

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The ability, possessed by all organisms, to respond to external stimulation is known as _______.


A) excitation
B) irritability
C) irritation
D) irrigation
E) receptiveness

F) A) and C)
G) C) and D)

Correct Answer

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Enzymes which play a role in maintaining cellular integrity by stabilizing membrane fluidity include all of the following EXCEPT:


A) dehydrogenases
B) desaturases
C) phospholipases
D) acyltransferases
E) phospholipid synthesizing enzymes

F) D) and E)
G) A) and E)

Correct Answer

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