Question 1

What is the molecular mechanism for imprinting a gene?

Accepted Answer

A)  Acetylation
B)  Nitration
C)  Phosphorylation
D)  MethylationE) None of the above
F) B) and D)

Question 2

In which cells do erasure and re-establishment of imprinting marks typically NOT occur?

Accepted Answer

A)  Nurse cells
B)  Sperm cells
C)  Oocytes
D)  Somatic cellsE) C) and D)
F) None of the above

Question 3

Where is extranuclear DNA located in mammalian cells?

Accepted Answer

A)  Endoplasmic reticulum
B)  Mitochondria
C)  Ribosome
D)  Plasma membraneE) All of the above
F) A) and B)

Question 4

Which diseases are associated with imprinting?

Accepted Answer

A)  Angelman Syndrome
B)  LHON
C)  Alzheimer's Disease
D)  All of the answers are correctE) None of the above
F) A) and D)

Question 5

What gene is most responsible for X-inactivation?

Accepted Answer

A)  Xic
B)  Xist
C)  Tsix
D)  XceE) A) and B)
F) A) and C)

Question 6

What genes appear to be controlled by the Xic?

Accepted Answer

A)  Xist and Tsix
B)  Xist only
C)  Tsix only
D)  None of theseE) All of the above
F) B) and D)

Question 7

If the sperm cell contributes mitochondria to the oocyte, it is called _______.

Accepted Answer

A)   paternal leakage
B)   maternal leakage
C)   paternal inheritance
D)   mitochondria
E)   imprintingF) D) and E)
G) B) and E) A

Question 8

What type of inheritance is observed with extranuclear DNA?

Accepted Answer

A)  Mendelian inheritance
B)  Sex-linked inheritance
C)  Paternal inheritance
D)  Maternal inheritance
E)   Maternal effectF) B) and E)
G) C) and E)

Question 9

Which of the following is false regarding mtDNA?

Accepted Answer

A)   It is around 17,000 bp in length
B)   It is a linear chromosome
C)   Multiple copies exist in each mitochondria
D)   It mostly contains rRNA and tRNA genesE) A) and B)
F) A) and C)

Question 10

Which of the following is primarily responsible for the maternal effect?

Accepted Answer

A)  Sperm cells
B)  Oocytes
C)  Nurse cells
D)  PlacentaE) A) and B)
F) A) and C)

Question 11

Dosage compensation offsets the problems associated with differences in the number of _______ chromosomes in many species.

Accepted Answer

A)   cytoplasmic
B)   autosome
C)   sex
D)   extranuclear
E)   mitochondrialF) B) and E)
G) All of the above

Question 12

What is a disease associated with extra nuclear inheritance?

Accepted Answer

A)  Angelman Syndrome
B)  Prader-Willi Syndrome
C)  LHON
D)  Muscular DystrophyE) B) and C)
F) A) and D) C

Question 13

In the gene that affects snail coiling, the ______ is responsible for the phenotype of the offspring.

Accepted Answer

A)   mother's phenotype
B)   father's phenotype
C)   mother's genotype
D)   father's genotypeE) A) and B)
F) None of the above C

Question 14

Most imprinted genes are silenced. What is one exception to this rule?

Accepted Answer

A)  H19
B)  Igf2
C)  UBE3A
D)  SNRPNE) B) and C)
F) B) and D)

Question 15

Heteroplasmy is associated with inheritance patterns involving

Accepted Answer

A)   nuclear.
B)   paternal DNA.
C)   chloroplasts.
D)   ribosomes.
E)   imprinted.F) A) and B)
G) A) and C)

Question 16

mtDNA stands for _______ and cpDNA stands for _______.

Accepted Answer

A)   extranuclear DNA, cytoplasmic DNA
B)   maternal DNA, paternal DNA
C)   marked DNA, copied DNA
D)   nuclear, cytoplasmic
E)   mitochondrial DNA, chloroplast DNAF) A) and C)
G) A) and E)

Question 17

How many Barr bodies would an individual with a XXY genotype possess?

Accepted Answer

A)  0
B)  1
C)  2
D)  None of the answers are correctE) C) and D)
F) None of the above

Question 18

In the Igf2 gene, which allele is imprinted? Which is expressed?

Accepted Answer

A)  Paternal, paternal
B)  Paternal, maternal
C)  Maternal, paternal
D)  Maternal, maternalE) A) and C)
F) B) and C)

Question 19

What encodes the toxin paramecin in Paramecia aurelia?

Accepted Answer

A)  mtDNA
B)  cpDNA
C)  Nuclear DNA
D)  Kappa particlesE) B) and C)
F) A) and D)

Question 20

The inheritance patterns of genetic material that is not contained in the nucleus of the cell is called _______.

Accepted Answer

A)  extranuclear inheritance
B)  maternal effect
C)  imprinting
D)  nuclear
E)  epigeneticF) C) and E)
G) D) and E)

Exam 5: Non-Mendelian Inheritance

What is the molecular mechanism for imprinting a gene?

Correct AnswerverifiedShow Answer

In which cells do erasure and re-establishment of imprinting marks typically NOT occur?

Correct AnswerverifiedShow Answer

Where is extranuclear DNA located in mammalian cells?

Correct AnswerverifiedShow Answer

Which diseases are associated with imprinting?

Correct AnswerverifiedShow Answer

What gene is most responsible for X-inactivation?

Correct AnswerverifiedShow Answer

What genes appear to be controlled by the Xic?

Correct AnswerverifiedShow Answer

If the sperm cell contributes mitochondria to the oocyte, it is called _______.

Correct AnswerverifiedA

What type of inheritance is observed with extranuclear DNA?

Correct AnswerverifiedShow Answer

Which of the following is false regarding mtDNA?

Correct AnswerverifiedShow Answer

Which of the following is primarily responsible for the maternal effect?

Correct AnswerverifiedShow Answer

Dosage compensation offsets the problems associated with differences in the number of _______ chromosomes in many species.

Correct AnswerverifiedShow Answer

What is a disease associated with extra nuclear inheritance?

Correct AnswerverifiedC

In the gene that affects snail coiling, the ______ is responsible for the phenotype of the offspring.

Correct AnswerverifiedC

Most imprinted genes are silenced. What is one exception to this rule?

Correct AnswerverifiedShow Answer

Heteroplasmy is associated with inheritance patterns involving

Correct AnswerverifiedShow Answer

mtDNA stands for _______ and cpDNA stands for _______.

Correct AnswerverifiedShow Answer

How many Barr bodies would an individual with a XXY genotype possess?

Correct AnswerverifiedShow Answer

In the Igf2 gene, which allele is imprinted? Which is expressed?

Correct AnswerverifiedShow Answer

What encodes the toxin paramecin in Paramecia aurelia?

Correct AnswerverifiedShow Answer

The inheritance patterns of genetic material that is not contained in the nucleus of the cell is called _______.

Correct AnswerverifiedShow Answer

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A

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C

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C

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mtDNA stands for _ and cpDNA stands for _.

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