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The term coverage,when applied to genomics,means sequencing:


A) every base pair of the entire genome.
B) every base pair of a single chromosome.
C) the same gene in multiple individuals.
D) the same gene in multiple species.
E) the same base pair multiple times.

F) C) and D)
G) A) and C)

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Pyrosequencing determines the nucleotide sequence because:


A) dideoxy nucleotides are incorporated into a growing DNA strand.
B) dideoxy nucleotides terminate the growing DNA strand.
C) PPi is incorporated into the growing DNA strand.
D) PPi is released from the growing DNA strand.
E) None of the answer options are correct.

F) A) and E)
G) A) and D)

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The genome of Hemophilus influenzae,the first free-living organism to have its genome sequenced,is how large?


A) 0) 5-megabase
B) 1.0-megabase
C) 1.8-megabase
D) 12-megabase
E) 18-megabase

F) A) and B)
G) None of the above

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Sanger DNA sequencing determines the nucleotide sequence because:


A) dideoxy nucleotides are incorporated into a growing DNA strand.
B) dideoxy nucleotides terminate the growing DNA strand.
C) PPi is incorporated into the growing DNA strand.
D) PPi is released from the growing DNA strand.
E) None of the answer options are correct.

F) D) and E)
G) A) and B)

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Which of the following is the most sensible order of techniques for mapping a chromosome and then locating a specific disease gene?


A) contig alignment;restriction mapping;RFLP linkage analysis;chromosomal walking
B) chromosomal walking;contig alignment;restriction mapping;RFLP linkage analysis
C) restriction mapping;chromosomal walking;contig alignment;RFLP linkage analysis
D) chromosomal walking;restriction mapping;RFLP linkage analysis;contig alignment
E) restriction mapping;contig alignment;RFLP linkage analysis;chromosomal walking

F) A) and E)
G) A) and D)

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Describe the information content of a genome.

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A gene can be viewed as an open-reading ...

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