Question 1

How many antigen-binding sites are present on an IgM molecule?

Accepted Answer

A)  2
B)  4
C)  10
D)  16
E)  25F) B) and E)
G) A) and E)

Question 2

The reaction of carbonic anhydrase catalyzes

Accepted Answer

A)  the formation of carbamates with the concomitant release of protons.
B)  the hydration of bicarbonate,resulting in the formation of carbonic acid.
C)  the reduction of carbon dioxide with the concomitant consumption of protons.
D)  the hydration of carbon dioxide,forming bicarbonate and protons.
E)  the hydrolysis of carbamates with the concomitant consumption of protons.F) B) and E)
G) B) and D)

Question 3

Which gas does not bind to the porphyrin ring Fe(II) ion in myoglobin?

Accepted Answer

A)  NO
B)  CO
C)  CO2
D)  O2
E)  H2SF) None of the above
G) A) and C)

Question 4

Which of the statements about muscle contraction is not true?

Accepted Answer

A)  During muscle contraction the sarcomere becomes shorter.
B)  During muscle contraction the I band becomes shorter.
C)  During muscle contraction the H zone becomes shorter.
D)  During muscle contraction the A band becomes shorter
E)  During muscle contraction the distance between the Z disk and the M disk becomes shorter.F) A) and E)
G) A) and B)

Question 5

The graph below shows the O2-binding curves for myoglobin (Mb)and hemoglobin (Hb).
a.Label the two curves (indicate which one represents Mb and which one represents Hb).  
b.Use the graph to determine the Kd of myoglobin for O2 (show your approach).
c.What is the difference between myoglobin and hemoglobin that cause the O2-binding curves to so be different?
d.Why is it important that hemoglobin has these particular O2-binding characteristics?

Accepted Answer

a.See graph.

b.K_d equals 3-4 torr (see ...

Question 6

What is the primary physiological function of myoglobin in most mammals?

Accepted Answer

The primary physiological func...

Question 7

The Bohr effect refers to

Accepted Answer

A)  the decrease in affinity of Hb for O2 when the pH goes down
B)  the decrease in affinity of Hb for O2 when the pH goes up
C)  the increase in the affinity of Hb for O2 when the O2 concentration goes up
D)  the decrease in affinity of Hb for O2 when the BPG concentration goes up
E)  the decrease in affinity of Hb for O2 when the BPG concentration goes downF) A) and B)
G) A) and C)

Question 8

Max Perutz's investigation of the structure of hemoglobin primarily utilized_____.

Accepted Answer

A)  X-ray crystallography
B)  NMR spectroscopy
C)  genomics
D)  mass spectrometry
E)  genetic engineeringF) A) and B)
G) A) and C)

Question 9

During muscle contraction myosin heads

Accepted Answer

A)  walk along thick filaments toward the M disk.
B)  walk along thick filaments toward the Z disk.
C)  walk along thin filaments toward the M disk.
D)  walk along the thin filaments toward the H zone.
E)  walk along the thin filaments toward the Z disk.F) All of the above
G) B) and D)

Question 10

During muscle contraction

Accepted Answer

A)  myosin pulls actin filaments toward the M disk.
B)  myosin pushes actin filaments toward the Z disk.
C)  actin pulls myosin toward the Z disk.
D)  actin pushes myosin toward the M disk.
E)  All of the answers above are correct.F) C) and D)
G) B) and E)

Question 11

Which of the following is not a ligand to the porphyrin ring Fe(II)  ion in oxymyoglobin?

Accepted Answer

A)  His E7
B)  His F8
C)  Nitrogen atoms in the porphyrin ring
D)  Oxygen
E)  all are ligandsF) C) and E)
G) C) and D)

Question 12

Hemoglobin's p50 value is about ______ as great as myoglobin's p50 value.

Accepted Answer

A)  one-tenth
B)  half
C)  twice
D)  ten times
E)  twenty timesF) B) and D)
G) A) and B)

Question 13

If the gene for myoglobin is "knocked out" in mice,the mice:

Accepted Answer

A)  have larger lungs.
B)  respire extremely rapidly.
C)  have dark brown muscle tissue.
D)  appear normal,with lighter colored muscle tissue.
E)  have their growth stunted.F) A) and B)
G) None of the above

Question 14

While the binding of O2 to myoglobin as a function of pO2 is described by a simple __________ curve,the binding to hemoglobin is described by a more complex ______ curve.

Accepted Answer

A)  sigmoidal;hyperbolic
B)  hyperbolic;sigmoidal
C)  exponential;hyperbolic
D)  sigmoidal;bell-shaped
E)  hyperbolic;concaveF) None of the above
G) C) and D)

Question 15

What is the type of symmetry that relates the protomers in hemoglobin with respect to each other?

Accepted Answer

A)  C2
B)  C4
C)  D2
D)  D4
E)  Tetrahedral symmetryF) B) and D)
G) C) and D)

Question 16

Which statement about antigen-binding sites in antibodies is false?

Accepted Answer

A)  An antigen-binding site on an IgG is formed by the amino-terminal ~110 amino acids of a light chain and the amino terminal ~110 amino acids of a heavy chain.
B)  An antigen-binding site on an IgG is formed by the variable region of a light chain and the variable region of a heavy chain.
C)  The antigen-binding site is composed of two Ig folds.
D)  Antigen-binding specificity is determined by the sequences of the hypervariable sequences in both the light chain and the heavy chain.
E)  Antigen binding specificity is determined exclusively by the sequences in the carboxy-terminal ~110 amino acids in the light chain and the heavy chain.F) A) and D)
G) A) and C)

Question 17

Matching

-Hemoglobin's subunits bind oxygen in a ______ manner.

Accepted Answer

A)   positively cooperative
B)   cyanosis
C)   His E7
D)   decrease
E)   RF)  hydrogen bondsG)  increaseH)  symmetryI)  His F8J)  ion pairsK)  TL)  hemolytic anemiaM)  sequencialN) I) and K)
O) C) and J)

Question 18

Humoral immunity is mediated by soluble molecules.Which cell type produces the soluble molecules that carry out the humoral immunity?

Accepted Answer

A)  T cells
B)  B cells
C)  macrophages
D)  neutrophils
E)  monocytesF) B) and D)
G) A) and B)

Question 19

Why is the decreased affinity of fetal hemoglobin for BPG advantageous?

Accepted Answer

A)  With fewer BPG molecules bound there are more heme residues available for O2 binding.
B)  Decreased BPG binding biases the fetal hemoglobin toward the R state.
C)  More free BPG is available to bind to adult hemoglobin,resulting in a shift to the R state.
D)  BPG is available to bind to fetal myoglobin,helping to release O2 in fetal muscle tissue.
E)  none of the aboveF) A) and D)
G) A) and B)

Question 20

In sickle-cell anemia,the negatively charged glutamic acid residue is replaced by the neutral amino acid ____________.

Accepted Answer

A)  tyrosine
B)  lysine
C)  valine
D)  adenosine
E)  glycineF) B) and D)
G) A) and B)

Exam 7: Protein Function Part I: Myoglobin and Hemoglobin

Which statement about antigen-binding sites in antibodies is false?

Correct Answer
verified

What is the primary physiological function of myoglobin in most mammals?

Correct Answer
verified
The primary physiological func...
View Answer

Correct Answer
verified
a.See graph.
b.K_d equals 3-4 torr (see ...
View Answer

Hemoglobin's p₅₀ value is about ______ as great as myoglobin's p₅₀ value.

Correct Answer
verified

Why is the decreased affinity of fetal hemoglobin for BPG advantageous?

Correct Answer
verified

During muscle contraction

Correct Answer
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The Bohr effect refers to

Correct Answer
verified

Which of the following is not a ligand to the porphyrin ring Fe(II) ion in oxymyoglobin?

Correct Answer
verified

During muscle contraction myosin heads

Correct Answer
verified

If the gene for myoglobin is "knocked out" in mice,the mice:

Correct Answer
verified

What is the type of symmetry that relates the protomers in hemoglobin with respect to each other?

Correct Answer
verified

The reaction of carbonic anhydrase catalyzes

Correct Answer
verified

Which of the statements about muscle contraction is not true?

Correct Answer
verified

How many antigen-binding sites are present on an IgM molecule?

Correct Answer
verified

Which gas does not bind to the porphyrin ring Fe(II) ion in myoglobin?

Correct Answer
verified

Max Perutz's investigation of the structure of hemoglobin primarily utilized_____.

Correct Answer
verified

Humoral immunity is mediated by soluble molecules.Which cell type produces the soluble molecules that carry out the humoral immunity?

Correct Answer
verified

Matching -Hemoglobin's subunits bind oxygen in a ______ manner.

Correct Answer
verified

While the binding of O₂ to myoglobin as a function of pO₂ is described by a simple ____ curve,thebinding to hemoglobin is described by a more complex curve.

Correct Answer
verified

In sickle-cell anemia,the negatively charged glutamic acid residue is replaced by the neutral amino acid ____________.

Correct Answer
verified

Exam 7: Protein Function Part I: Myoglobin and Hemoglobin

Which statement about antigen-binding sites in antibodies is false?

Correct AnswerverifiedShow Answer

What is the primary physiological function of myoglobin in most mammals?

Correct AnswerverifiedThe primary physiological func...View AnswerShow Answer

Correct Answerverifieda.See graph. b.Kd equals 3-4 torr (see ...View AnswerShow Answer

Hemoglobin's p50 value is about ______ as great as myoglobin's p50 value.

Correct AnswerverifiedShow Answer

Why is the decreased affinity of fetal hemoglobin for BPG advantageous?

Correct AnswerverifiedShow Answer

During muscle contraction

Correct AnswerverifiedShow Answer

The Bohr effect refers to

Correct AnswerverifiedShow Answer

Which of the following is not a ligand to the porphyrin ring Fe(II) ion in oxymyoglobin?

Correct AnswerverifiedShow Answer

During muscle contraction myosin heads

Correct AnswerverifiedShow Answer

If the gene for myoglobin is "knocked out" in mice,the mice:

Correct AnswerverifiedShow Answer

What is the type of symmetry that relates the protomers in hemoglobin with respect to each other?

Correct AnswerverifiedShow Answer

The reaction of carbonic anhydrase catalyzes

Correct AnswerverifiedShow Answer

Which of the statements about muscle contraction is not true?

Correct AnswerverifiedShow Answer

How many antigen-binding sites are present on an IgM molecule?

Correct AnswerverifiedShow Answer

Which gas does not bind to the porphyrin ring Fe(II) ion in myoglobin?

Correct AnswerverifiedShow Answer

Max Perutz's investigation of the structure of hemoglobin primarily utilized_____.

Correct AnswerverifiedShow Answer

Humoral immunity is mediated by soluble molecules.Which cell type produces the soluble molecules that carry out the humoral immunity?

Correct AnswerverifiedShow Answer

Matching -Hemoglobin's subunits bind oxygen in a ______ manner.

Correct AnswerverifiedShow Answer

While the binding of O2 to myoglobin as a function of pO2 is described by a simple __________ curve,the binding to hemoglobin is described by a more complex ______ curve.

Correct AnswerverifiedShow Answer

In sickle-cell anemia,the negatively charged glutamic acid residue is replaced by the neutral amino acid ____________.

Correct AnswerverifiedShow Answer

Correct Answer
verified

Correct Answer
verified
The primary physiological func...
View Answer

Correct Answer
verified
a.See graph.
b.K_d equals 3-4 torr (see ...
View Answer

Hemoglobin's p₅₀ value is about ______ as great as myoglobin's p₅₀ value.

Correct Answer
verified

Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
verified

While the binding of O₂ to myoglobin as a function of pO₂ is described by a simple ____ curve,thebinding to hemoglobin is described by a more complex curve.

Correct Answer
verified

Correct Answer
verified