Question 1

Polysomes are

Accepted Answer

A)   polycistronic messengers bound to RNA polymerase.
B)   polycistronic messengers bound to DNA polymerase.
C)   polycistronic messengers bound to a single ribosome.
D)   a group of ribosomes bound to different sections of the same mRNA with each ribosome engaged in the synthesis of the same kind of polypeptide chain.
E)   none of the aboveF) D) and E)
G) A) and B)

Question 2

Genes containing intervening sequences (or introns)

Accepted Answer

A)   are rare in eukaryotic cells.
B)   code for mRNA precursors which must be spliced before translation.
C)   must undergo a DNA rearrangement before expression.
D)   do not code for proteins.
E)   are common in prokaryotes.F) A) and C)
G) A) and D)

Question 3

Regarding regulation of transcription, which of the following statements is correct?

Accepted Answer

A)   The CAP protein-cAMP complex binds the lac repressor thereby permitting transcription of the lac operon.
B)   The lac repressor is a small piece of RNA which binds the operator region of the lac operon.
C)   The operator region of the lac operon is less than 150 base pairs in length.
D)   The z gene of the lac operon codes for the lac repressor.
E)   All of the above.F) A) and C)
G) B) and D)

Question 4

What is the main function of the nucleolus?

Accepted Answer

A)   Site of synthesis of ribosomal protein.
B)   Site of synthesis of ribosomal RNA.
C)   Site of synthesis of DNA which directs formation of transfer RNA.
D)   Site of synthesis of messenger RNA.
E)   Site of messenger RNA translation.F) B) and E)
G) A) and B)

Question 5

Mammalian RNA polymerase II

Accepted Answer

A)   synthesizes rRNA.
B)   synthesizes mRNA.
C)   synthesizes tRNA.
D)   is least sensitive to alpha-amanitin.
E)   None of the other answers is correct.F) None of the above
G) A) and B)

Question 6

Which of the following RNAs are synthesized in the nucleolus?

Accepted Answer

A)   5S rRNA
B)   tRNA
C)   28S rRNA
D)   mRNA
E)   Both A and CF) B) and E)
G) A) and D)

Question 7

The synthesis of which of the following eukaryotic RNAs would be most severely inhibited by the mushroom toxin alpha-amanitin?

Accepted Answer

A)   mitochondrial RNA
B)   hnRNA
C)   rRNA
D)   tRNA
E)   7SL RNAF) A) and B)
G) B) and D)

Question 8

A drug that specifically affects the activity of RNA polymerase I would be expected to most DIRECTLY affect which of the following processes?

Accepted Answer

A)   ribosome assembly
B)   spliceosome assembly
C)   synthesis of RNA polymerases II and III.
D)   regulation of RNA polymerases II and III.
E)   assembly of the RNA polymerase I, II and III complex.F) C) and D)
G) B) and C)

Question 9

All of the following are determinants of transcription activation EXCEPT

Accepted Answer

A)   Trans_acting proteins and cofactors.
B)   Cis_acting elements.
C)   mRNA processing.
D)   Locus arrangement.
E)   Chromatin structure.F) None of the above
G) B) and E)

Question 10

All of the following are CORRECT statements about the process of transcription (in vivo)  EXCEPT

Accepted Answer

A)   accurate transcription involves a protein called sigma which permits RNA polymerase to bind and initiate transcription at specific sites on the DNA molecule.
B)   the entire DNA molecule is transcribed once transcription begins.
C)   an mRNA produced as a result of transcription may code for more than one polypeptide chain in prokaryotes.
D)   a newly synthesized RNA molecule is complementary in base sequence to only one strand of the DNA which served as template.E) All of the above
F) A) and D)

Question 11

Which of the following is not characteristic of tRNAs?

Accepted Answer

A)   They form extensive secondary structure.
B)   They have many modified bases.
C)   They are spliced post-transcriptionally.
D)   They get nucleotides added to their end post- transcriptionally.
E)   They contain the codon for translation.F) A) and E)
G) None of the above

Question 12

Splicing occurs

Accepted Answer

A)   in the nucleus, by removing introns from DNA.
B)   in the nucleus, prior to transcription.
C)   in the nucleus, either during or subsequent to transcription.
D)   in the cytoplasm, prior to translation.
E)   in the cytoplasm, subsequent to translation.F) B) and E)
G) D) and E)

Question 13

Alternative splicing of mRNA precursors

Accepted Answer

A)   allows the production of different protein products from one gene.
B)   is usually the consequence of deleterious mutations.
C)   allows two or more genes to contribute to the production of a single protein.
D)   gives rise to random mRNA isoforms.E) All of the above
F) B) and C)

Question 14

Regarding RNA synthesis, which of the following statements is correct?

Accepted Answer

A)   The rho subunit is required for chain initiation.
B)   Synthesis of mRNA from a DNA template strand occurs in a 5 ==> direction anti-parallel to the template.
C)   The first nucleotide placed in an RNA transcript of prokaryotic cells is GTP and ATP.
D)   Both A and B are correct.
E)   Both B and C are correct.F) A) and B)
G) A) and C)

Question 15

Leucine zipper domains found in many transcription factors function directly in

Accepted Answer

A)   DNA binding.
B)   transactivation.
C)   dimerization.
D)   zinc binding.E) C) and D)
F) B) and C)

Question 16

In mammalian cells, cytosolic rRNA

Accepted Answer

A)   is composed of 4 different size classes of RNA.
B)   is rapidly degraded during protein synthesis.
C)   is composed of only two types of rRNA.
D)   contains the codons for protein synthesis.
E)   is part of the and 6S subunits.F) C) and E)
G) B) and E)

Question 17

Transcription of the following DNA segment proceeds from left to right. ..ATTCAG.5' 5'.TAAGTC. The sequence of the resulting RNA is

Accepted Answer

A)   5'.GUCUUA.
B)   5'.AUUCUG.
C)   5'.UAAGUC.
D)   5'.CUGAAU.
E)   none of the above.F) B) and C)
G) A) and C)

Question 18

The messenger RNA codon for histidine is CAU. The sequence of the DNA template strand for this mRNA is (all written 5' to

Accepted Answer

A)   GTA.
B)   ATG.
C)   CAU.
D)   CAT.
E)   none of the aboveF) B) and E)
G) C) and D)

Question 19

All of the statements concerning the cap on mRNA are TRUE EXCEPT

Accepted Answer

A)   the methyl groups are contributed by S-adenosyl methionine.
B)   it is located at the 5' end of eukaryotic mRNA.
C)   its structure includes 7 methyl guanine.
D)   its structure may include 2'0-methyl groups.
E)   an RNA polymerase is responsible for adding this structure to the primary transcript.F) A) and B)
G) C) and D)

Question 20

The synthesis of RNA complementary to one strand of the DNA is termed

Accepted Answer

A)   translation.
B)   replication.
C)   reverse transcription.
D)   transcription.
E)   transformation.F) B) and D)
G) None of the above

Exam 5: RNA: Transcription and Rna Processing

All of the statements concerning the cap on mRNA are TRUE EXCEPT

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Regarding regulation of transcription, which of the following statements is correct?

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Which of the following is not characteristic of tRNAs?

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What is the main function of the nucleolus?

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Polysomes are

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Alternative splicing of mRNA precursors

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The synthesis of RNA complementary to one strand of the DNA is termed

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The messenger RNA codon for histidine is CAU. The sequence of the DNA template strand for this mRNA is (all written 5' to

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Splicing occurs

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Leucine zipper domains found in many transcription factors function directly in

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All of the following are CORRECT statements about the process of transcription (in vivo) EXCEPT

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Which of the following RNAs are synthesized in the nucleolus?

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In mammalian cells, cytosolic rRNA

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Genes containing intervening sequences (or introns)

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Transcription of the following DNA segment proceeds from left to right. ..ATTCAG.5' 5'.TAAGTC. The sequence of the resulting RNA is

Correct AnswerverifiedShow Answer

A drug that specifically affects the activity of RNA polymerase I would be expected to most DIRECTLY affect which of the following processes?

Correct AnswerverifiedShow Answer

All of the following are determinants of transcription activation EXCEPT

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Mammalian RNA polymerase II

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Regarding RNA synthesis, which of the following statements is correct?

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The synthesis of which of the following eukaryotic RNAs would be most severely inhibited by the mushroom toxin alpha-amanitin?

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