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Which amino acid has a phenol in its side chain?


A) tyrosine
B) tryptophan
C) isoleucine
D) asparagine
E) histidine

F) A) and B)
G) A) and E)

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Disulfide linkages can form between:


A) two cysteine residues.
B) two methionine residues.
C) a cysteine residue and a methionine residue.
D) two threonine residues.
E) a methionine residue and a threonine residue.

F) D) and E)
G) B) and E)

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Which of the following amino acids has its isoelectric point at the highest pH?


A) glutamic acid
B) lysine
C) serine
D) histisdine
E) cysteine

F) C) and D)
G) A) and E)

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Draw the structure of Lys-Phe-Leu at biological pH.

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Provide the single letter code for the following peptide Arg-Phe-Tyr-Cys-Asp-Trp-Gln-Ala-Glu-Glu-His-Lys

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Draw the Fischer projection of L-valine at a pH of 12.

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Which amino acid has an amide group in its side chain?


A) tyrosine
B) tryptophan
C) isoleucine
D) asparagine
E) histidine

F) A) and C)
G) A) and B)

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Provide the structure of the major organic product which results when L-phenylalanine is treated with a large excess of PhCH2OH and gaseous HCl.

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When the structure of a small dipeptide was examined using NMR, it was observed that the carbonyl oxygen atoms in the backbone structure are nearly always trans with respect to the H atoms on the amide nitrogens. Explain this observation and include diagrams.

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Apparently the extra unshared electrons ...

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Provide the structure of L-aspartic acid at pH 12.0.

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What name is given to a protein infectious agent that is thought to promote misfolding and polymerization of normal protein molecules and that is believed to cause Creutzfeldt-Jakob Disease?

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Which amino acid has an imidazole ring in its side chain?


A) tyrosine
B) tryptophan
C) isoleucine
D) asparagine
E) histidine

F) A) and C)
G) A) and B)

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Draw structures for the forms of glycine present in basic, neutral, and acidic solutions.

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Most naturally occurring amino acids are L-amino acids. Does this mean they are levorotatory? Explain.

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No, this does not mean they are levorota...

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The primary structure of a protein refers to:


A) the sequence of its amino acids.
B) the orientation of α-helices.
C) the orientation of pleated sheets.
D) the orientation of peptide subunits within a complex protein.
E) the placement of the protein's active site.

F) A) and B)
G) C) and E)

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What is the major end product of the following reaction series? What is the major end product of the following reaction series?   A)  Ala B)  Gly C)  Leu D)  Ile E)  Val


A) Ala
B) Gly
C) Leu
D) Ile
E) Val

F) A) and E)
G) C) and D)

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The H-bonds formed in the tertiary structure of proteins can be differentiated from those formed in secondary structures. What is the major distinguishing factor?


A) The H-bonds in 3° structures are significantly stronger than those found in 2° structures.
B) The H-bonds in 3° structures are more random than those formed in 2° structures.
C) The H-bonds in 3° structures are formed by predictable interactions among the peptide backbone α-amine and α-carboxylate groups.
D) The H-bonds in 3° structures are formed by interactions involving the side chain R-groups.
E) Both B and D are correct.

F) D) and E)
G) None of the above

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Before Edman degradation, Fredrick Sanger developed the first method to analyze the N-terminal amino acid of a protein using 2,4-dinitrofluorobenzene in the following reaction. Propose a mechanism for this reaction. Before Edman degradation, Fredrick Sanger developed the first method to analyze the N-terminal amino acid of a protein using 2,4-dinitrofluorobenzene in the following reaction. Propose a mechanism for this reaction.

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Classic Nucleophilic...

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Which of the following amino acids has its isoelectric point at the lowest pH?


A) arginine
B) glutamic acid
C) valine
D) glycine
E) methionine

F) A) and E)
G) C) and D)

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Provide a reasonable synthesis of PhCH2CH(NH3+)CO2H from BrCH(CO2CH2CH3)2.

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1. potassium phthali...

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